Effect of S-Allyl –L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis
Identifieur interne : 000165 ( an2020/Analysis ); précédent : 000164; suivant : 000166Effect of S-Allyl –L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis
Auteurs : Patrycja Bronowicka-Adamska ; Anna Bentke ; Małgorzata Lasota ; Maria Wr BelSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2020.
Abstract
The S-Allyl-L-cysteine (SAC) component of aged garlic extract (AGE) is proven to have anticancer, antihepatotoxic, neuroprotective and neurotrophic properties. γ-Cystathionase (CTH), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine. The aim of the study was to determine the effect of SAC on MCF-7 cells survival and apoptosis, which is a widely known approach to reduce the number of cancer cells. An additional goal of this paper was to investigate the effect of SAC on the activity and expression of enzymes involved in H2S production. The experiments were carried out in the human breast adenocarcinoma cell line MCF-7. Changes in the cell viability were determined by MTT assay. Cell survival was determined by flow cytometry (FC). Changes in enzymes expression were analyzed using Western blot. After 24 h and 48 h incubation with 2245 µM SAC, induction of late apoptosis was observed. A decrease in cell viability was observed with increasing SAC concentration and incubation time. SAC had no significant cytotoxic effect on the MCF-7 cells upon all analyzed concentrations. CTH, MPST and CBS expression were confirmed in non-treated MCF-7 cells. Significant decrease in MPST activity at 2245 µM SAC after 24 h and 48 h incubation vs. 1000 µM SAC was associated with decrease in sulfane sulfur levels. The presented results show promising SAC effects regarding the deterioration of the MCF-7 cells’ condition in reducing their viability through the downregulation of MPST expression and sulfate sulfur level reduction.
Url:
DOI: 10.3390/ijms21031090
PubMed: 32041330
PubMed Central: 7037078
Affiliations:
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Kraków, Poland;<email>patrycja.bronowicka-adamska@uj.edu.pl</email> (P.B.-A.);<email>anna.bentke@uj.edu.pl</email> (A.B.)</nlm:aff></affiliation></author><author><name sortKey="Lasota, Malgorzata" sort="Lasota, Malgorzata" uniqKey="Lasota M" first="Małgorzata" last="Lasota">Małgorzata Lasota</name><affiliation><nlm:aff id="af2-ijms-21-01090">Institute of Pediatrics, Department of Transplantation, Faculty of Medicine, Jagiellonian University Medical College, Wielicka 265, 30-663 Kraków, Poland;<email>malgorzata.lasota@uj.edu.pl</email></nlm:aff></affiliation></author><author><name sortKey="Wr Bel, Maria" sort="Wr Bel, Maria" uniqKey="Wr Bel M" first="Maria" last="Wr Bel">Maria Wr Bel</name><affiliation><nlm:aff id="af1-ijms-21-01090">Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Kraków, Poland;<email>patrycja.bronowicka-adamska@uj.edu.pl</email> (P.B.-A.);<email>anna.bentke@uj.edu.pl</email> 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last="Bentke">Anna Bentke</name><affiliation><nlm:aff id="af1-ijms-21-01090">Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Kraków, Poland;<email>patrycja.bronowicka-adamska@uj.edu.pl</email> (P.B.-A.);<email>anna.bentke@uj.edu.pl</email> (A.B.)</nlm:aff></affiliation></author><author><name sortKey="Lasota, Malgorzata" sort="Lasota, Malgorzata" uniqKey="Lasota M" first="Małgorzata" last="Lasota">Małgorzata Lasota</name><affiliation><nlm:aff id="af2-ijms-21-01090">Institute of Pediatrics, Department of Transplantation, Faculty of Medicine, Jagiellonian University Medical College, Wielicka 265, 30-663 Kraków, Poland;<email>malgorzata.lasota@uj.edu.pl</email></nlm:aff></affiliation></author><author><name sortKey="Wr Bel, Maria" sort="Wr Bel, Maria" uniqKey="Wr Bel M" first="Maria" last="Wr Bel">Maria Wr Bel</name><affiliation><nlm:aff id="af1-ijms-21-01090">Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Kraków, Poland;<email>patrycja.bronowicka-adamska@uj.edu.pl</email> (P.B.-A.);<email>anna.bentke@uj.edu.pl</email> (A.B.)</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The S-Allyl-L-cysteine (SAC) component of aged garlic extract (AGE) is proven to have anticancer, antihepatotoxic, neuroprotective and neurotrophic properties. γ-Cystathionase (CTH), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H<sub>2</sub>S/sulfane sulfur endogenous formation from L-cysteine. The aim of the study was to determine the effect of SAC on MCF-7 cells survival and apoptosis, which is a widely known approach to reduce the number of cancer cells. An additional goal of this paper was to investigate the effect of SAC on the activity and expression of enzymes involved in H<sub>2</sub>S production. The experiments were carried out in the human breast adenocarcinoma cell line MCF-7. Changes in the cell viability were determined by MTT assay. Cell survival was determined by flow cytometry (FC). Changes in enzymes expression were analyzed using Western blot. After 24 h and 48 h incubation with 2245 µM SAC, induction of late apoptosis was observed. A decrease in cell viability was observed with increasing SAC concentration and incubation time. SAC had no significant cytotoxic effect on the MCF-7 cells upon all analyzed concentrations. CTH, MPST and CBS expression were confirmed in non-treated MCF-7 cells. Significant decrease in MPST activity at 2245 µM SAC after 24 h and 48 h incubation vs. 1000 µM SAC was associated with decrease in sulfane sulfur levels. The presented results show promising SAC effects regarding the deterioration of the MCF-7 cells’ condition in reducing their viability through the downregulation of MPST expression and sulfate sulfur level reduction. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Colin Gonzalez, A L" uniqKey="Colin Gonzalez A">A.L. Colín-González</name></author><author><name sortKey="Santana, R A" uniqKey="Santana R">R.A. Santana</name></author><author><name sortKey="Silva Islas, C A" uniqKey="Silva Islas C">C.A. Silva-Islas</name></author><author><name sortKey="Chanez Cardenas, M E" uniqKey="Chanez Cardenas M">M.E. Chánez-Cárdenas</name></author><author><name sortKey="Santamaria, A" uniqKey="Santamaria A">A. 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Bradford</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bentke, Anna" sort="Bentke, Anna" uniqKey="Bentke A" first="Anna" last="Bentke">Anna Bentke</name><name sortKey="Bronowicka Adamska, Patrycja" sort="Bronowicka Adamska, Patrycja" uniqKey="Bronowicka Adamska P" first="Patrycja" last="Bronowicka-Adamska">Patrycja Bronowicka-Adamska</name><name sortKey="Lasota, Malgorzata" sort="Lasota, Malgorzata" uniqKey="Lasota M" first="Małgorzata" last="Lasota">Małgorzata Lasota</name><name sortKey="Wr Bel, Maria" sort="Wr Bel, Maria" uniqKey="Wr Bel M" first="Maria" last="Wr Bel">Maria Wr Bel</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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